Immunology
The articles listed here are updated regularly and address cutting-edge research addressing the unique immunology found in the liver.
Proteomic Signatures of Myeloid Derived Suppressor Cells from Liver and Lung Metastases Reveal Functional Divergence and Potential Therapeutic Targets
Myeloid-derived suppressor cells (MDSCs) promote immunosuppressive activities in the tumor microenvironment (TME), resulting in increased tumor burden and diminishing the anti-tumor response of immunotherapies. While primary and metastatic tumors are typically the...
The Immunological and Metabolic Landscape in Primary and Metastatic Liver Cancer
The liver is the sixth most common site of primary cancer in humans, and generally arises in a background of cirrhosis and inflammation. Moreover, the liver is frequently colonized by metastases from cancers of other organs (particularly the colon) because of its...
Liver Metastasis Restrains Immunotherapy Efficacy via Macrophage-Mediated T Cell Elimination
Metastasis is the primary cause of cancer mortality, and cancer frequently metastasizes to the liver. It is not clear whether liver immune tolerance mechanisms contribute to cancer outcomes. We report that liver metastases diminish immunotherapy efficacy systemically...
Improving the Efficacy of Liver Cancer Immunotherapy: The Power of Combined Preclinical and Clinical Studies
There is no effective mechanism-based therapy available for hepatocellular carcinoma (HCC). Therefore, following the “miracle” outcomes seen in a few patients at the advanced stages of melanoma or lung cancer, the immune checkpoint inhibitors (ICIs) immediately...
HITM-SURE: Hepatic Immunotherapy for Metastases Phase Ib anti-CEA CAR-T Study Utilizing Pressure Enabled Drug Delivery
In recent years, cell therapy technologies have resulted in impressive results in hematologic malignancies. Treatment of solid tumors with chimeric antigen receptor T-cells (CAR-T) has been less successful. Solid tumors present challenges not encountered with...
Top 10 Challenges in Cancer Immunotherapy
Cancer immunotherapy is a validated and critically important approach for treating patients with cancer. Given the vast research and clinical investigation efforts dedicated to advancing both endogenous and synthetic immunotherapy approaches, there is a need to focus...
Challenges to Assessing Tumor Responses to Immunotherapy
It is essential to develop a deeper understanding of radiographic responses to immunotherapy such that clinical benefit is not underappreciated in individual patients and during clinical investigation. With the advent of immunotherapy as an integral component of...
STAT3 Inhibition Induces Bax-Dependent Apoptosis in Liver Tumor Myeloid-Derived Suppressor Cells
It is essential to develop a deeper understanding of radiographic responses to immunotherapy such that clinical benefit is not underappreciated in individual patients and during clinical investigation. With the advent of immunotherapy as an integral component of...
Immunosuppression in Liver Tumors: Opening the Portal to Effective Immunotherapy
This review summarizes the immunobiology of the intrahepatic space and how this knowledge enables identification of hurdles and potential solutions to the barriers facing immunotherapy for liver tumors. Substantial progress has been seen with immunotherapy for...